Benefits of NIR spectroscopy: Part 4
08.04.2020
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How pre-calibrations assist quick implementation of NIRS
This is part four in our series about NIR spectroscopy. In this installment, it is outlined in which cases NIRS can be implemented directly in your laboratory without the need for any method development. This means that for these applications your instrument is immediately operational to deliver accurate results – right from day one. At the end of this blog post, we provide an overview of several applications for which it is possible to get immediate results from the beginning.
The following topics will be covered in the rest of this post (click to jump to the topic):
Introduction
In our last installment (Part 3: How to implement NIRS in your laboratory workflow), we showed how a newly received NIR spectrometer can become operational with a real application example. This process is depicted here in Figure 1.
The majority of work consists of creating a calibration set. Approximately 40–50 samples across the expected parameter range must be measured by a primary method, and resulting values need to be linked to the NIR spectra recorded for the same samples (Figure 1: Step 1).
Thereafter, a prediction model needs to be created by visually identifying the spectral changes and correlating these changes to the values obtained from the primary method (Figure 1: Step 2). After validation by the software, a prediction model is available for use in routine measurements.
The process described above requires some effort and is of significant duration because in many cases, the samples spanning the concentration range first need to be produced and collected. Therefore, it would be very beneficial if steps 1 and 2 could be omitted so that the analyzer can be used immediately from day one.
This is not just wishful thinking, but rather the reality for specific applications with the use of pre-calibrations.
