Ion chromatography applications
Ion chromatography (IC), or ion exchange chromatography is a powerful analytical technique used to separate and quantify ions in a sample. By leveraging the principles of ion exchange and conductivity detection, IC delivers precise and reliable results across various applications. Our application experts have compiled numerous documents for various industries, including environmental, food and beverage, and pharmaceuticals.
Use the filters to search for IC applications by analyte/parameter, sample matrix, norm, or industry.
- AN-S-404Water quality testing with EPA 300.1
The Metrosep A Supp 21 column and 948 Continuous IC Module, CEP enable efficient, automated single-run analysis of major anions and disinfection byproducts in water.
- AB-380Installation Instruction for ProfIC Vario 7 Cation
This document describes the recommended equipment and installation of a Professional IC Vario system with combined MISP techniques of Inline Dilution and Inline Dialysis.
- AB-379Installation Instruction for ProfIC Vario 7 Anion
This document describes the recommended equipment and installation of a Professional IC Vario system with combined MISP techniques of Inline Dilution and Inline Dialysis.
- AN-C-198Calcium acetate assay in calcium acetate capsules
The assay of calcium acetate, often used as a phosphate binder for dialysis patients, can be performed with ion chromatography (IC) as per USP <621> and <1225>.
- AN-C-197Potassium assay in potassium citrate and citric acid oral solution
Potassium citrate and citric acid oral solutions act as systemic alkalizers. Potassium assays, validated per USP <621> and <1225>, use IC with L76 cation-exchange columns.
- AN-CIC-035Halogens and sulfur in solid samples according to EN 17813
Organic halides must be monitored in the environment. Combustion ion chromatography (CIC) is used for accurate halogen analysis in solids following EN 17813:2023.
- AN-C-195Cation quantification with increased performance using microbore IC
Microbore ion chromatography offers better sensitivity, shorter retention times, and consumes less eluent, increasing sample throughput and reducing running costs.
- AN-C-196Purity quantification of tris(hydroxymethyl)aminomethane (TRIS) with IC
Tris(hydroxymethyl)aminomethane (TRIS) is often used in life science applications and its purity must be monitored. This analysis is possible with ion chromatography.
- AN-CS-007Lithium in addition to other cations in seepage water from minerals through sequential suppression
With the advent of electric automobiles, the demand for lithium batteries and with it the demand for lithium material will increase sharply. Brine lakes and hard silicate minerals are numbered among the most important sources of lithium. This Application Note addresses cation determination in seepage water from lithium minerals. Alkali and earth alkali metals are separated in the lithium digestions on the Metrosep C Supp 1 - 250/4.0 column, with subsequent conductivity detection after sequential suppression.
- WP-065Simplified sulfite determination in foods and beverages using ion chromatography
Sulfites are well-known additives in foods and beverages used to extend shelf life and preserve colors. Such properties have led to the broad usage of sulfites in a range of foodstuffs like fruits, cereals, vegetables, seafood, juices, alcoholic and non-alcoholic (soft) beverages, and in some meat products. The term «sulfites» describes a group of molecules that include sulfur dioxide (SO2) and chemically related molecules like sodium sulfite (Na2SO3), sodium bisulfite (NaHSO3), or sodium metabisulfite (Na2S2O5). Sulfite intake has been correlated with several adverse reactions, and therefore sulfites are included in the FAO/WHO Codex Alimentarius list. Labelling sulfite content in foods and beverages is necessary when the total concentration exceeds 10 mg/kg. Metrohm ion chromatography allows the reliable measurement of sulfite in different matrices using either conductivity or amperometric detection. The inclusion of automated sample preparation and cleaning steps with Metrohm instrumentation saves additional analyst time and helps increase sample throughput.
