AN-S-286
根据USP 33 - NF 28 Suppl. 1，托吡酯中的硫酸盐和硫胺酸盐分析
概要
Topiramate is an antiepilepsy drug. According to USP Topiramate tablets have to be tested for impurities. The determination of sulfate and sulfamate is mentioned under 'Specific Tests'. The isocratic method applies a column eluent combination primarily used for non-suppressed IC. But as sulfamate shows a negative peak under theses conditions the use of suppression is advantageous.