AN-K-004
Water in lyophilizates (e.g., vaccines in sample vials)
Tóm tắt
The water content of lyophilisates contained in vials is determined by Karl Fischer titration. Conditioned solvent (methanol) is injected into the vial to dissolve the sample and extract the water (ultrasonic bath). Afterwards the contents of the vial are transferred to the titration vessel to carry out the automatic determination.