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AB-358

Analysis of residual moisture in a lyophilized pharmaceutical product by near-infrared spectroscopy (NIRS)


Resumo

This Application Bulletin describes the method of near-infrared spectroscopy in diffuse reflection for the purpose of determining residual moisture in a lyophilized pharmaceutical product. Numerous sample vials containing freeze-dried pharmaceuticals were spiked with varying amounts of water for calibration purposes. The resulting differences in the absorption wavelengths of the OH-oscillation were correlated with the water content determined by Karl Fischer titration using the algorithm of multiple linear regression (MLR).

Contato

Metrohm Portugal

R. Frei Luis de Granada 14G
1500-680 Lisboa

Contato