AN-NIR-087
2020-12
Ethanol content in hand sanitizers
Fast and reagent-free ethanol content determination
Summary
In 2020, the demand for hand sanitizer skyrocketed due to the COVID-19 pandemic. Many companies shifted gears, streamlining their operations to produce hand sanitizer in large volumes. As in any product manufacturing process, accurate formulation enables good quality and minimizes waste. The alcohol content in hand sanitizers must be greater than 60% (v/v) to be an effective antiseptic. Reagents commonly used in these solutions are water, alcohol (commonly ethanol or isopropanol), small amounts of emollient (skin softener, e.g. glycerol), and an oxidizing agent (e.g. hydrogen peroxide) to minimize microbial contamination.
A safe and fast way to monitor ethanol content in these sanitizing solutions is with reagent-free near-infrared spectroscopy, which provides reliable results in a few seconds, quickly indicating when adjustments in formulation are necessary.
Results
All 13 measured Vis-NIR spectra (Figure 2) were used to create a prediction model for quantification of the ethanol content. The quality of the prediction models was evaluated using correlation diagrams, which display a very high correlation between VisNIR prediction and primary method values. The respective figures of merit (FOM) display the expected precision of a prediction during routine analysis.
Figures of merit | Value |
---|---|
R2 | 0.9977 |
Standard error of calibration | 0.41 v/v% |
Standard error of cross-validation | 0.56 v/v% |
Conclusion
This application note demonstrates the feasibility of the DS2500 Liquid Analyzer for the determination of ethanol in hand sanitizer products. Vis-NIR spectroscopy enables a fast determination with high accuracy, and therefore represents a suitable alternative to the standard method.
Parameter | Method | Time to result and workflow |
---|---|---|
Ethanol content | GC | ∼5 min (preparation) + ∼5 min (GC) |