แอปพลิเคชัน
- 8.000.6102Ion chromatography – the all-rounder for pharmaceutical analysis
Pharmaceutical analysis guarantees drug safety by providing information on the identity, content, quality, purity, and stability of pharmaceutical products using analytical chemistry. Ion chromatography (IC) offers a broad range of pharmacopeia-compliant applications for quality control, monitoring, and improving drug manufacturing.As a very accurate and versatile technique, IC meets the requirements of many pharmaceutical applications. IC is a USP-accepted standard method for the determination of active pharmaceutical ingredients (APIs), excipients, impurities,pharmaceutical solutions as well as pharmaceutical starting materials, finished pharmaceutical products (FPPs) and even body fluids.This poster describes some typical examples.
- AN-C-111N-methylpyrrolidone impurity in Cefepime Hydrochloride
Determination of N-methylpyrrolidone (N-MP) in a pharmaceutical product (Cefepime Hydrochloride) using cation chromatography with direct conductivity detection.
- AN-CS-008Determination of dimethylamine in meropenem using sequential suppression
Meropenem is a beta-lactam antibiotic that is classed among the carbapenems; it suppresses murein biosynthesis and thus the buildup of the bacterial cell wall. Dimethylamine is an important precursor in meropenem synthesis and must therefore be monitored as an impurity. Detection is performed on the Metrosep C Supp 1 - 250/4 column with subsequent conductivity detection after sequential suppression.
- AN-K-039Water in penicillin-G-potassium
This application note describes the water content determination in penicillin by using volumetric Karl Fischer titration. Unwanted side reactions can be avoided by using special solvent mixtures.
- AN-P-037Gentamicin sulfate using pulsed amperometric detection in accordance with Ph. Eur.
Determination of gentamicin sulfate with pulsed amperometric detection and post-column reaction with NaOH. Keyword: Antibiotics
- AN-P-080Content of gentamicin according to USP applying pulsed amperometric detection
Gentamicin is an aminoglycoside antibiotic and is composed of a number of related gentamicins. It is applied for several types of infections. For the determination of the major components, USP asks for chromatographic separation with pulsed amperometric detection using a gold working electrode. A post-column addition of NaOH is performed prior to the detection.
- AN-S-224Sulfate in gentamicin sulfate
Determination of sulfate in gentamicin sulfate using anion chromatography with conductivity detection after chemical suppression.
- AN-T-017Determination of ampicillin content
Determination of ampicillin in raw and pure products through potentiometric titration with Hg(II) using the combined Au electrode. Keyword: Antibiotics
- AN-T-018Determination of total penicillin content
Determination of total penicillin content through potentiometric titration with Hg(II) using the combined Au electrode. Keyword: Antibiotics
- AN-T-040Determination of phenylglycine content
Determination of phenylglycine through nonaqueous potentiometric titration with sodium methylate using a special combined glass electrode. Keyword: Antibiotics
- AN-U-027System suitability test for cefazolin in accordance with USP
Determination of cefazolin in accordance with USP 28-NF 23 (Appendix 2) using RP chromatography and subsequent UV detection. Keyword: Antibiotics
- AN-U-029Analysis of cloxacillin sodium in accordance with USP
Determination of cloxacillin sodium in accordance with USP 28-NF 23 (Appendix 2) using RP chromatography and subsequent UV detection. Keyword: Antibiotics
- AN-U-030System suitability test for amoxicillin in accordance with USP
Determination of amoxicillin in accordance with USP 28-NF 23 (Appendix 2) using RP chromatography and subsequent UV detection. Keyword: Antibiotics
- AN-U-037System suitability test for penicillin G potassium in accordance with USP
Determination of penicillin G potassium and 2-phenyl acetamide in accordance with USP 28-NF 23 (Appendix 2) using RP chromatography and subsequent UV detection. Keyword: Antibiotics
- AN-U-043Sample determination of cefadroxil in accordance with USP
Determination of cefadroxil in accordance with USP 28-NF 23 (Supplement 2) using RP chromatography with UV detection. Keyword: Antibiotics
- TA-037Amperometric detection – a detection method for complex analytical tasks
Ion chromatography is used as a high-performance analysis method in numerous applications. For complex analysis tasks, alternative detectors such as the amperometric detector or the UV/VIS detector are often also used in addition to the conductivity detector. This article describes the areas of utilization of the amperometric detector. Catchword: Antibiotics
- WP-017Near-infrared spectroscopy in pharmacopoeias
The pharmaceutical industry is very likely more comprehensively regulated that any other branch of industry. It therefore requires analytic methods that meet the requirements of regulations while at the same time being practical. This applies in particular for large sample quantities, such as are encountered with incoming goods inspections, for example. It is here that particularly rapid and simple analysis methods are called for which make routine analyses simpler and more efficient. This White Paper describes some of the most important regulations in the pharmaceutical analysis and shows how Vis-NIR spectroscopy can solve analytic problems in the pharmaceutical industry in accordance with regulations.
- WP-019Ion chromatography – a universal technique with many applications in the pharmaceutical industry
Ion chromatography is a flexible technique with a large selection of intended uses in the pharmaceutical industry. – A few development trends and the latest advances are displayed here.