Applications
- 8.000.6102Ion chromatography – the all-rounder for pharmaceutical analysis
Pharmaceutical analysis guarantees drug safety by providing information on the identity, content, quality, purity, and stability of pharmaceutical products using analytical chemistry. Ion chromatography (IC) offers a broad range of pharmacopeia-compliant applications for quality control, monitoring, and improving drug manufacturing.As a very accurate and versatile technique, IC meets the requirements of many pharmaceutical applications. IC is a USP-accepted standard method for the determination of active pharmaceutical ingredients (APIs), excipients, impurities,pharmaceutical solutions as well as pharmaceutical starting materials, finished pharmaceutical products (FPPs) and even body fluids.This poster describes some typical examples.
- AN-C-111N-methylpyrrolidone impurity in Cefepime Hydrochloride
Determination of N-methylpyrrolidone (N-MP) in a pharmaceutical product (Cefepime Hydrochloride) using cation chromatography with direct conductivity detection.
- AN-CS-008Determination of dimethylamine in meropenem using sequential suppression
Meropenem is a beta-lactam antibiotic that is classed among the carbapenems; it suppresses murein biosynthesis and thus the buildup of the bacterial cell wall. Dimethylamine is an important precursor in meropenem synthesis and must therefore be monitored as an impurity. Detection is performed on the Metrosep C Supp 1 - 250/4 column with subsequent conductivity detection after sequential suppression.
- AN-K-039Water in penicillin-G-potassium
This application note describes the water content determination in penicillin by using volumetric Karl Fischer titration. Unwanted side reactions can be avoided by using special solvent mixtures.
- AN-P-037Gentamicin sulfate using pulsed amperometric detection in accordance with Ph. Eur.
Determination of gentamicin sulfate with pulsed amperometric detection and post-column reaction with NaOH. Keyword: Antibiotics
- AN-P-080Content of gentamicin according to USP applying pulsed amperometric detection
Gentamicin is an aminoglycoside antibiotic and is composed of a number of related gentamicins. It is applied for several types of infections. For the determination of the major components, USP asks for chromatographic separation with pulsed amperometric detection using a gold working electrode. A post-column addition of NaOH is performed prior to the detection.
- AN-S-224Sulfate in gentamicin sulfate
Determination of sulfate in gentamicin sulfate using anion chromatography with conductivity detection after chemical suppression.
- AN-T-017Determination of ampicillin content
Determination of ampicillin in raw and pure products through potentiometric titration with Hg(II) using the combined Au electrode. Keyword: Antibiotics
- AN-T-018Determination of total penicillin content
Determination of total penicillin content through potentiometric titration with Hg(II) using the combined Au electrode. Keyword: Antibiotics
- AN-T-040Determination of phenylglycine content
Determination of phenylglycine through nonaqueous potentiometric titration with sodium methylate using a special combined glass electrode. Keyword: Antibiotics