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News (1)2.945.0010
945 Professional Detector Vario – ConductivityIntelligent stand-alone detector equipped with a high-performance IC Conductivity Detector. For use with intelligent IC instruments or as independent conductivity detector.
2.945.0020
945 Professional Detector Vario – AmperometryIntelligent stand-alone detector equipped with the IC Amperometric Detector. Outstanding selectivity due to the four measuring modes: DC, PAD, flexIPAD, CV. The excellent signal/noise ratio and the very fast start-up guarantee the highest in measurement precision. For use with intelligent IC instruments or as independent detector.
2.945.0030
945 Professional Detector Vario – Conductivity & AmperometryIntelligent stand-alone detector equipped with the high performance IC Conductivity Detector and the IC Amperometric Detector, with the four measuring modes DC, PAD, flexIPAD and CV. For use with intelligent IC instruments or as independent detector for conductivity and amperometric detection.
- AN-C-197AN-C-197Potassium assay in potassium citrate and citric acid oral solution
Potassium citrate and citric acid oral solutions act as systemic alkalizers. Potassium assays, validated per USP <621> and <1225>, use IC with L76 cation-exchange columns.
- AN-P-087AN-P-087Quality labels for novel foods
This Application Note presents an update to the standard AOAC method for total GOS determination in foodstuffs.
- AN-CS-021Sodium in sodium bicarbonate and sodium phosphates compounded injections
Compounded injections of sodium bicarbonate are sterile solutions for correcting metabolic acidosis and other conditions requiring systemic alkalinization. Compounded injections of sodium phosphates serve as a phosphate source to either prevent or correct hypophosphatemia in patients with restricted oral intake. Ion chromatography (IC) with suppressed conductivity detection is the standardized way to accurately quantify sodium in these solutions.
- AN-BAT-016AN-BAT-016EIS at different states of charge with INTELLO
This application shows how EIS, combined with INTELLO and NOVA, tracks changes in internal battery resistance across SOC levels to study performance and aging mechanisms.
- AN-S-376Fluoride in sodium fluoride gel for pharmaceutical use
Sodium fluoride gel for pharmaceutical use needs to comply with USP requirements. The actual monograph (USP 42) uses two different methods for the identification and the assay. Ion chromatography allows the analysis of these two parameters in one single determination. In the course of the USP monograph modernization, this ion chromatographic approach makes this type of analysis even easier.
- AN-S-375Fluoride in sodium fluoride for pharmaceutical use
Dental care products often contain sodium fluoride as an active ingredient. Manufacturers use the United States Pharmacopeia and National Formulary (USP-NF) Monograph «Sodium Fluoride» to quantify sodium fluoride and its anionic contaminants chloride and acetate in these products. The validated USP method proposes ion chromatography (IC) with suppressed conductivity detection to carry out the fluoride assay as well as the impurity determination in a single chromatogram.
- AN-S-379Fluoride in sodium fluoride tablets for pharmaceutical use
Sodium fluoride tablets for pharmaceutical use need to comply with U.S. Pharmacopeia (USP) requirements. Ion chromatography (IC) with suppressed conductivity detection has been approved by the USP as a validated method to quantify fluoride content in sodium fluoride tablets. In the course of the USP monograph modernization, using automated IC makes this type of analysis even easier.
- AN-S-380Monofluorophosphate and fluoride in sodium monofluorophosphate for pharmaceutical use
Ion chromatography (IC) with suppressed conductivity detection has been approved by the U.S. Pharmacopeia (USP) as a validated method to quantify the monofluorophosphate (MFP) content in sodium monofluorophosphate. This Application Note shows that all acceptance criteria for the USP Monograph «Sodium Monofluorophosphate» are fulfilled and the procedure was approved as a validated USP method.
- AN-S-397IC assay for sodium chloride in sodium chloride tablets for solution
As an alternative to titration, ion chromatography (IC) with suppressed conductivity detection has been approved by USP as validated method to quantify chloride content in NaCl tablets for solution or oral use.
- AN-S-399IC assay for fluoride in sodium fluoride and acidulated phosphate topical solution
Anticavity pharmaceuticals like sodium fluoride and acidulated phosphate topical solution products require strict quality control. This Application Note outlines the fluoride IC assay as described in the USP Monograph Sodium Fluoride and Acidulated Phosphate Topical Solution.
- Feb 26, 2024Ensuring and certifying quality and compliance in regulated environments
Metrohm's AOAC Installation & Operational Qualification (Q2)-certified instruments provide peace of mind by simplifying the process of meeting regulatory requirements.
- Nov 18, 2024Ion chromatography for the pharmaceutical industry
The principles of ion chromatography are introduced, then some applications and benefits of using IC for pharma analysis according to USP General Chapter <1065>.
- May 25, 2020Photometric complexometric titration
What is photometric complexometric titration and how does it work, read our chemistry blog.
- Sep 14, 2020History of Metrohm IC – Part 3
Blog post on Metrohm ion chromatography and the introduction of sequential suppression for increased sensitivity in ion chromatographic analysis.
- Oct 16, 2023Applying USP validated methods for separation column equivalency
The modernization of USP Monographs now permits a broader selection of separation columns for pharmaceutical analysis using ion chromatography (IC). Column equivalency studies enable the use of alternative analytical columns without needing complicated method validation procedures. This benefits pharma researchers by saving time and effort while maintaining the accuracy and reliability of analytical results in accordance with validated methods.
- 8.945.50018.945.5001Brochure: 945 Professional Detector Vario IC Amperometric Detector – Amperometric detection for the determination of electroactive substances
Amperometric detectors are an alternative to conductivity and UV/VIS detectors. They are used when electroactive – i.e. oxidizable or reducible – substances are to be determined. The amperometric detector exists as an embedded detector – the IC Amperometric Detector – and as a stand-alone detector – the 945 Professional Detector Vario. The present brochure describes these two instruments
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- 8.945.30048.945.3004Declaration of Conformity for 945 Professional Detector Vario
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- 8.945.80018.945.8001Manual for 29450010 Professional Detector Vario Cond
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- 8.945.80028.945.8002Manual for 29450020 Professional Detector Vario Amp
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- 8.945.80038.945.8003Manual for 29450030 Professional Detector Vario Conductivity & Amperometry
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- 8.894.50038.894.5003894 Professional CVS – Cyclic Voltammetric Stripping for the determination of additives in electroplating baths
The 894 Professional CVS together with viva software is the most powerful CVS system for the determination of organic additives in electroplating baths. The 894 Professional CVS stands out for its unique flexibility. Due to the system’s entirely modular design, it can be expanded and upgraded at any time with additional units such as dosing devices, pumps, and sample changers.
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