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- AN-NIR-011Transferability of a calibration model for caffeine on the NIRS XDS Rapid Content Analyzer
This Application Note demonstrates that a calibration model for caffeine and microcrystalline cellulose developed on the NIRS XDS Rapid Content Analyzer (RCA) is transferable to other NIRS XDS RCA. Due to the improved signal-to-noise ratio, reduced bandwidth and improved wavelength precision of the NIRS XDS, the transferability of the calibration model can be easily and efficiently performed.
- AN-NIR-012Increase the accuracy of your NIR measurements with instrument calibration
This Application Note describes how the accuracy of your NIR measurements can be increased with instrument calibration.
- WP-043Instrument Calibration, System Verification, and Performance Validation for Metrohm Instant Raman Analyzers (Mira)
Analytical Instrument Qualification (AIQ) according to the United States Pharmacopeia (USP) ensures that instruments perform as intended and users may have confidence in data quality. As the Pharma industry adopts handheld Raman instruments for incoming materials identification and verification, producers of such systems must provide suitable calibration and validation routines. Upon completion of these tests, end users are assured that all measurements are in accordance with agreed standards at Metrohm Raman, we have sophisticated AIQ routines in place to confirm the quality of your results.
- AN-NIR-109Determination of Brix, fructose, glucose, and sucrose with NIRS
Key quality parameters in the food industry include sucrose, glucose, and fructose, and Brix (dissolved sugar content). Near-infrared spectroscopy (NIRS) allows fast simultaneous determination of multiple sugars without chemicals or any sample preparation.
- AB-358Analysis of residual moisture in a lyophilized pharmaceutical product by near-infrared spectroscopy (NIRS)
This Application Bulletin describes the method of near-infrared spectroscopy in diffuse reflection for the purpose of determining residual moisture in a lyophilized pharmaceutical product. Numerous sample vials containing freeze-dried pharmaceuticals were spiked with varying amounts of water for calibration purposes. The resulting differences in the absorption wavelengths of the OH-oscillation were correlated with the water content determined by Karl Fischer titration using the algorithm of multiple linear regression (MLR).
- AN-NIR-117Analysis of moisture, ash, carbon, and volatile content in coal by NIRS
Conventional methods used to analyze moisture, ash, fixed carbon, and volatile content in coal samples, are time consuming and costly. Near-infrared (NIR) spectroscopy is excellently suited to determine all parameters simultaneously in less than one minute without any sample preparation.
- AN-NIR-041Multiparameter Quality Control of Lubricants with NIRS
For lubricant analysis, determination of the Acid Number (ASTM D664), viscosity (ASTM D445), moisture content (ASTM D6304), and color number (ASTM D1500) require the use of multiple analytical technologies and, in part, large volumes of chemicals. This application note demonstrates that the XDS RapidLiquid Analyzer operating in the visible and near-infrared spectral region (Vis-NIR) provides a fast and cost-efficient alternative for the determination of the AN, viscosity, moisture content, and color number of lubricants. With no sample preparation or chemicals needed, Vis-NIR spectroscopy allows for multi parameter analysis of lubricants in less than one minute.
- AN-NIR-119Moisture content and rheology determination of fluorinated polyolefins using NIRS
Near-infrared spectroscopy streamlines ethylene tetrafluoroethylene production by offering rapid, chemical-free analysis of melt flow rate and moisture content.
- AN-NIR-106Quality control of non-nutritive sweeteners with NIR spectroscopy
Near-infrared spectroscopy (NIRS) allows the simultaneous determination of sweeteners such as Stevia and sucralose in blends in less than one minute without any chemicals or sample preparation.
- AN-NIR-063Content uniformity test of pharmaceutical solid dosage forms using NIR spectroscopy
Uniformity of dosage units must be tested for QC purposes in the pharma industry. NIRS gives results in seconds along with the quantification of APIs and excipients.